As an excipient, gelatin is a key component in many vaccine formulations. Well-known examples include the Fluenz Tetra (Astra Zeneca), MMR-II and MMR VaxPro (Merck), VariVax (Merck), YF-Vax (Sanofi), and Zostavax (Merck) vaccines. In this webinar, we will elaborate gelatin’s functionalities as a protective agent and collapse-temperature modifier during the lyophilization process and as a stabilizer to help maintain the effectiveness of live-attenuated vaccines during shelf life. The use of ultra-pure pharmaceutical gelatins in formulation testing is recommended even at the preclinical stage to develop safe vaccines. A specially purified gelatin, with low endotoxin levels, is used as a stabilizer in some vaccines.

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